Isotopic generator for bismuth-212 and lead-212 based on radium

Patent · Wed Jan 30 00:00:00 EST 1985

OSTI ID:5273678

Hines, J J; Atcher, R W; Friedman, A M

Disclosed are method and apparatus for providing radionuclides of bismuth-212 and lead-212. Thorium-228 and carrier solution starting material is input to a radiologically contained portion of an isotopic generator system, and radium-224 is separated from thorium-228 which is retained by a strongly basic anion exchange column. The separated radium-224 is transferred to an accessible, strongly acidic cationic exchange column. The cationic column retains the radium-224, and natural radioactive decay generates bismuth-212 and lead-212. The cationic exchange column can also be separated from the contained portion of the system and utilized without the extraordinary safety measures necessary in the contained portion. Furthermore, the cationic exchange column provides over a relatively long time period the short lived lead-212 and bismuth-212 radionuclides which are useful for a variety of medical therapies.

• Research Organization: Argonne National Laboratory (ANL), Argonne, IL (United States)
• DOE Contract Number: W-31-109-ENG-38
• Assignee: Dept. of Energy
• Application Number: ON: DE85017786
• OSTI ID: 5273678
• Resource Relation: Other Information: Portions of this document are illegible in microfiche products
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
BISMUTH 212
RADIOISOTOPE GENERATORS
LEAD 212
RADIUM 224
THORIUM 228
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BISMUTH ISOTOPES
DAYS LIVING RADIOISOTOPES
EVEN-EVEN NUCLEI
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
ISOTOPES
LEAD ISOTOPES
NUCLEI
ODD-ODD NUCLEI
RADIOISOTOPES
RADIUM ISOTOPES
THORIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
400703* - Radiochemistry & Nuclear Chemistry- Radioisotope Production