Polycatecholamide chelating agents

Patent · Sun Jan 01 04:00:00 EST 1984

OSTI ID:864952

Weitl, Frederick L ^[1]; Raymond, Kenneth N ^[2]

---

1. Martinez, CA
2. Berkeley, CA

Novel polybenzamide compounds useful for in vitro or in vivo chelation are described. The compounds have the formula ##STR1## Polyamines are reacted with 2,3-dimethoxy benzoyl chloride unsubstituted or substituted with SO.sub.3 H, SO.sub.3 M, NO.sub.2, CO.sub.2 H or CO.sub.2 M as desired is reacted with a polyamine in an inert solvent then demethylated with BBr.sub.3 or BCl.sub.3 in an inert solvent. Where compounds symmetrically substituted on the terminal N's are desired, the polyamine is first reductively alkylated by reaction with an aldehyde or ketone and the resulting Schiff base is hydrogenated.

• Research Organization: Lawrence Livermore National Laboratory (LLNL), Livermore, CA
• DOE Contract Number: W-7405-ENG-48
• Assignee: United States of America as represented by United States (Washington, DC)
• Patent Number(s): US 4442305
• OSTI ID: 864952
• Country of Publication: United States
• Language: English

Related Subjects

/514/423/999/
3-dimethoxy
agents
aldehyde
alkylated
base
bbr
bcl
benzoyl
chelating
chelating agent
chelating agents
chelation
chloride
compounds
compounds useful
demethylated
described
desired
formula
hydrogenated
inert
inert solvent
ketone
novel
polyamine
polyamines
polybenzamide
polycatecholamide
reacted
reaction
reductively
resulting
schiff
schiff base
solvent
str1
substituted
symmetrically
terminal
unsubstituted
useful
vitro
vivo