Polycatecholamide chelating agents

Patent · Tue Apr 10 00:00:00 EST 1984

OSTI ID:7254118

Weitl, F L; Raymond, K N

Novel polybenzamide compounds useful for in vitro or in vivo chelation are described. The compounds have the formula given in patent. Polyamines are reacted with 2,3-dimethoxy benzoyl chloride unsubstituted or substituted with SO[sub 3]H, SO[sub 3]M, NO[sub 2], CO[sub 2]H or CO[sub 2]M as desired is reacted with a polyamine in an inert solvent then demethylated with BBr[sub 3] or BCl[sub 3] in an inert solvent. Where compounds symmetrically substituted on the terminal N's are desired, the polyamine is first reductively alkylated by reaction with an aldehyde or ketone and the resulting Schiff base is hydrogenated. No Drawings

• DOE Contract Number: W-7405-ENG-48
• Assignee: Dept. of Energy, Washington, DC (United States)
• Patent Number(s): US 4442305; A
• Application Number: PPN: US 6-295512
• OSTI ID: 7254118
• Resource Relation: Patent File Date: 24 Aug 1981
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CHELATING AGENTS
CHEMICAL PREPARATION
ALKYLATION
CHEMICAL REACTIONS
SCHIFF BASES
IMINES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
SYNTHESIS
550600* - Medicine