Liquid-phase chromatography detector

Patent · Fri Dec 31 23:00:00 EST 1982

OSTI ID:864764

Voigtman, Edward G.; Winefordner, James D.; Jurgensen, Arthur R.

A liquid-phase chromatography detector comprising a flow cell having an inlet tubular conduit for receiving a liquid chromatographic effluent and discharging it as a flowing columnar stream onto a vertically adjustable receiving surface spaced apart from and located vertically below and in close proximity to the discharge end of the tubular conduit; a receiver adapted to receive liquid overflowing from the receiving surface; an exit conduit for continuously removing liquid from the receiver; a light source for focussing fluorescence-producing light pulses on the flowing columnar stream as it passes from the outlet of the conduit to the receiving surface and a fluorescence detector to detect the produced fluorescence; a source of light pulse for producing acoustic waves in the columnar stream as it passes from the conduit outlet to the receiving surface; and a piezoelectric transducer adapted to detect those waves; and a source of bias voltage applied to the inlet tubular conduit and adapted to produce ionization of the liquid flowing through the flow cell so as to produce photocurrents therein and an electrical system to detect and record the photocurrents. This system is useful in separating and detecting individual chemical compounds from mixtures thereof.

• Research Organization: University of Florida, Gainesville, FL (United States)
• Sponsoring Organization: USDOE; National Institutes of Health (NIH)
• DOE Contract Number: AS05-78OR06022
• Assignee: University of Florida (Gainesville, FL)
• Patent Number(s): 4,413,504
• Application Number: 06/382,633
• OSTI ID: 864764
• Country of Publication: United States
• Language: English

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/73/250/356/
acoustic
acoustic wave
acoustic waves
adapted
adjustable
apart
applied
below
bias
bias voltage
cell
chemical
chemical compound
chemical compounds
chromatographic
chromatography
chromatography detector
close
close proximity
columnar
compounds
comprising
conduit
continuously
currents therein
detect
detecting
detector
detector comprising
discharge
discharging
effluent
electrical
exit
flow
flow cell
flowing
flowing columnar
fluorescence
fluorescence detector
fluorescence-producing
focussing
individual
inlet
ionization
light
light pulse
light pulses
light source
liquid
liquid chromatograph
liquid chromatographic
liquid flow
liquid flowing
liquid-phase
liquid-phase chromatography
located
located vertically
mixtures
moving liquid
outlet
overflowing
passes
photocurrents
piezoelectric
piezoelectric transducer
produce
produced
producing
proximity
pulse
pulses
receive
receive liquid
receiver
receiving
receiving surface
record
removing
removing liquid
separating
source
spaced
spaced apart
stream
surface
surface spaced
therein
transducer
tubular
useful
vertically
vertically adjustable
vertically below
voltage
voltage applied
waves