Obesity in BSB mice is correlated with expression of genes foriron homeostasis and leptin
Journal Article
·
· Obesity Research
OSTI ID:861129
Obesity is a complex disease. To date, over 100 chromosomal loci for body weight, body fat, regional white adipose tissue weight, and other obesity-related traits have been identified in humans and in animal models. For most loci, the underlying genes are not yet identified; some of these chromosomal loci will be alleles of known obesity genes, whereas many will represent alleles of unknown genes. Microarray analysis allows simultaneous multiple gene and pathway discovery. cDNA and oligonucleotide arrays are commonly used to identify differentially expressed genes by surveys of large numbers of known and unnamed genes. Two papers previously identified genes differentially expressed in adipose tissue of mouse models of obesity and diabetes by analysis of hybridization to Affymetrix oligonucleotide chips.
- Research Organization:
- Ernest Orlando Lawrence Berkeley NationalLaboratory, Berkeley, CA (US)
- Sponsoring Organization:
- USDOE Director. Office of Science. Office of Biological andEnvironmental Research
- DOE Contract Number:
- AC02-05CH11231
- OSTI ID:
- 861129
- Report Number(s):
- LBNL--55214; BnR: KP1103010
- Journal Information:
- Obesity Research, Journal Name: Obesity Research Journal Issue: 2 Vol. 12
- Country of Publication:
- United States
- Language:
- English
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