CYP1B1 expression, a potential risk factor for breast cancer
Journal Article
·
· Polycyclic Aromatic Compounds
OSTI ID:835332
- LBNL Library
CYP1B1 expression in non-tumor breast tissue from breast cancer patients and cancer-free individuals was determined to test the hypothesis that high CYP1B1 expression is a risk factor for breast cancer. Large interindividual variations in CYP1B1 expression were found with CYP1B1 levels notably higher in breast cancer patients than cancer-free individuals. The results indicate that CYP1B1 might play a role in breast cancer either through increased PAH activation or through metabolism of endogenous estrogen to a carcinogenic derivative.
- Research Organization:
- Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA (US)
- Sponsoring Organization:
- US Department of Energy; US Army Medical Research and Materiel Command Grant DAMD17-98-1-8062 (US)
- DOE Contract Number:
- AC03-76SF00098
- OSTI ID:
- 835332
- Report Number(s):
- LBNL--48024
- Journal Information:
- Polycyclic Aromatic Compounds, Journal Name: Polycyclic Aromatic Compounds Journal Issue: 3 Vol. 23
- Country of Publication:
- United States
- Language:
- English
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