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Specific expression of the pS2 gene in subclasses of breast cancers in comparison with expression of the estrogen and progesterone receptors and the oncogene ERBB2

Journal Article · · Proc. Natl. Acad. Sci. U.S.A.; (United States)
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The expression of the pS2 gene, which is induced by estrogen in the breast cancer cell line MCF-7, has been investigated in breast cancers by using pS2 mRNA determination in tumor specimens and immunocytochemistry to identify pS2 protein in paraffin-embedded sections. Using these assays the authors show that determination of pS2 gene expression allows the definition of subclasses of estrogen-receptor-containing breast cancers that may be used to more precisely identify estrogen-dependent tumors. Tumor specimens have also been analyzed for the presence of mRNAs for the estrogen receptor and for the ERBB2 oncogene. No evidence for the presence of truncated forms of estrogen-receptor mRNA has been found, and overexpression of the ERBB2 oncogene did not correlate with the steroid receptor status of pS2 gene expression.

Research Organization:
Institut de Chimie Biologique, Strasbourg (France)
OSTI ID:
6469866
Journal Information:
Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 84:24; ISSN PNASA
Country of Publication:
United States
Language:
English

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550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMISTRY
BODY
CARCINOMAS
CHEMISTRY
CYTOCHEMISTRY
DAYS LIVING RADIOISOTOPES
DISEASES
ESTROGENS
GENES
GLANDS
HORMONES
HYBRIDIZATION
IMMUNOLOGY
ISOTOPES
KETONES
LIGHT NUCLEI
MAMMARY GLANDS
MEMBRANE PROTEINS
MESSENGER-RNA
MOLECULAR BIOLOGY
NEOPLASMS
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ONCOGENES
ORGANIC COMPOUNDS
ORGANS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PREGNANES
PROGESTERONE
PROTEINS
RADIOISOTOPES
RECEPTORS
RNA
STEROID HORMONES
STEROIDS
TUMOR CELLS