Crystal Structure of Rhodopsin: A Template for Cone Visual Pigments and Other G Protein-coupled Receptors
- SLAC
The crystal structure of rhodopsin has provided the first three-dimensional molecular model for a G-protein-coupled receptor (GPCR). Alignment of the molecular model from the crystallographic structure with the helical axes seen in cryo-electron microscopic (cryo-EM) studies provides an opportunity to investigate the properties of the molecule as a function of orientation and location within the membrane. In addition, the structure provides a starting point for modeling and rational experimental approaches of the cone pigments, the GPCRs in cone cells responsible for color vision. Homology models of the cone pigments provide a means of understanding the roles of amino acid sequence differences that shift the absorption maximum of the retinal chromophore in the environments of different opsins.
- Research Organization:
- Stanford Linear Accelerator Center, Menlo Park, CA (US); Stanford Synchrotron Radiation Lab. (US)
- Sponsoring Organization:
- USDOE Office of Science (US)
- DOE Contract Number:
- AC03-76SF00515
- OSTI ID:
- 815901
- Report Number(s):
- SLAC-REPRINT-2002-306
- Journal Information:
- Biochimica et Biophysica Acta, Journal Name: Biochimica et Biophysica Acta
- Country of Publication:
- United States
- Language:
- English
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