Analysis of survival of C-18 cells after irradiation in suspension with chelated and ionic bismuth-212 using microdosimetry
- DePaul Univ., Chicago, IL (United States)
- Univ. of Chicago, IL (United States)
A previous analysis of non-stochastic dose based on data obtained during irradiations of C-18 cells in suspension by {alpha} particles emitted from two forms (chelated and ionic) of {sup 212}Bi was made using survival curves. No appreciable difference in slope (1/D{sub o}) was found between the two forms. Such non-stochastic analyses do not account for the large differences in specific energies deposited in the individual cell nuclei. This microdosimetric (1/z{sub o}) of the individual C-18 cells using the distribution of specific energies deposited in the individual cell nuclei. The resulting sensitivity is greater for the {alpha} particles emitted from the chelated {sup 212}Bi than from the ionic {sup 212}Bi. An attempt to account for this greater sensitivity in terms of greater LET of {alpha} particles passing through the cell nuclei from the chelated {sup 212}Bi is unsuccessful. Instead the greater sensitivity disappears if the microdosimetric analysis uses average values for the radii of the cell and of its nucleus rather than the values (from the peak in the cell size distribution) used by the non-stochastic dose analysis. 13 refs., 7 figs.
- Research Organization:
- Argonne National Laboratory (ANL), Argonne, IL
- DOE Contract Number:
- FG02-88ER60661; W-31109-ENG-38
- OSTI ID:
- 79330
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Journal Issue: 1 Vol. 140; ISSN RAREAE; ISSN 0033-7587
- Country of Publication:
- United States
- Language:
- English
Similar Records
Cellular uptake of {sup 212}BiOCl by Ehrlich ascites cells: A dosimetric analysis
Biological effect of lead-212 localized in the nucleus of mammalian cells: Role of recoil energy in the radiotoxicity of internal alpha-particle emitters
Radioimmunotherapy of peritoneal human colon cancer xenografts with site-specifically modified sup 212 Bi-labeled antibody
Conference
·
Thu Dec 31 23:00:00 EST 1998
·
OSTI ID:684485
Biological effect of lead-212 localized in the nucleus of mammalian cells: Role of recoil energy in the radiotoxicity of internal alpha-particle emitters
Journal Article
·
Mon Oct 31 23:00:00 EST 1994
· Radiation Research
·
OSTI ID:70212
Radioimmunotherapy of peritoneal human colon cancer xenografts with site-specifically modified sup 212 Bi-labeled antibody
Journal Article
·
Wed Jan 31 23:00:00 EST 1990
· Cancer Research; (USA)
·
OSTI ID:6938076