Non-Invasive Optical Measurements Final Report CRADA No. TC-1070-94

Technical Report · Wed Feb 25 04:00:00 EST 1998

DOI:https://doi.org/10.2172/757025· OSTI ID:757025

Da Silva, L ^[1]

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1. LLNL

Optical low-coherence reflectometry (OCLR) is a non-invasive optical technique for imaging into highly scattering media. In this collaboration, LLNL and Novametrix Medical Systems, Inc. evaluated the potential of OCLR to measure the concentration of blood constiuents. A fiber optic scanning OCLR system was developed and used to measure the penetration limits into a variety of animal tissue. The results indicate that OCLR can probe Up to 3 mm into tissue and accurately measure the transversed path length and the total attenuation coefficient. A dual wavelength OCLR system operating at 1300nm and 1500nnl demonstrated the use of this technique to quantify water content in human skin. Additional optical sources operating at different wavelengths will allow OLCR to be combined with standard absorption spectroscopy techniques. Ultimately, this will provide a safe, inexpensive spectroscopic system able to non-invasively quantify blood constituents several millimeters into tissue.

• Research Organization: Lawrence Livermore National Laboratory (LLNL), Livermore, CA
• Sponsoring Organization: USDOE Office of Defense Programs (DP)
• DOE Contract Number: W-7405-ENG-48
• OSTI ID: 757025
• Report Number(s): UCRL-ID-138163; LLNL--TR-747181; CRADA No. TC-1070-94
• Country of Publication: United States
• Language: English

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