Nucleotide sequence of a novel HLA-DRB1 allele, DRB1*0806
- Univ. of Elm (Germany)
Human major histocompatibility complex (HLA) class II genes are organized in three subregions, DR, DQ, and DP. The genes in this region are extremely polymorphic and new alleles are continuously being identified. We report here a novel allele that was found by the amplification and direct sequencing of exon 2 of DRB1. The novel allele was found in a bone marrow transplantation patient, the mother, and two serologically identified donors. The patient was typed as DR3/DR8, the mother as DR2/DR8, and the father as DR3/DR8 heterozygote. Therefore, the patient inherited the DR3 haplotype from the father and the DR8 haplotype from the mother. At first, it was not possible to definitely determine the subtype of the DR8 allele by oligotyping. 4 refs., 1 fig.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 75578
- Journal Information:
- Immunogenetics, Journal Name: Immunogenetics Journal Issue: 1 Vol. 41; ISSN IMNGBK; ISSN 0093-7711
- Country of Publication:
- United States
- Language:
- English
Similar Records
Identification of the new HLA-DRB1{sup *}0812 allele detected by sequencing based typing
The role of HLA class II genes in insulin-dependent diabetes mellitus: Molecular analysis of 180 Caucasian, multiplex families