A new DRB1 allele (DRB1*0811) identified in Native Americans
- Blood Systems Central Lab., Scottsdale, AZ (United States)
- Univ. of New Mexico, Albuquerque, NM (United States)
A novel DRB1 allele was identified in a potential bone marrow transplantation recipient and her father. Both are Native Americans of Navajo descent. Class II serologic typing of the patient demonstrated the presence of DR8, DR14, DR52, and DQ3. Sequence specific polymerase chain reaction (PCR) amplification of genomic DNA was consistent with the DRB1 alleles *08 and *14. Direct DNA sequencing of PCR products prepared from genomic DNA demonstrated that the patient`s class II alleles included the novel allele, DRB1*1402, DRB3*0101, DQB1*0301, and DQB1*0402. Analysis of the siblings and the father of this individual revealed that the new allele was transmitted on the haplotype A2, Cw7, B39, DQB1*0402, while the DRB1*1402 allele was transmitted on the haplotype A24, Cw4, B35, DRB3*0101, DQB1*0301. 4 refs., 1 fig., 1 tab.
- OSTI ID:
- 68503
- Journal Information:
- Immunogenetics, Journal Name: Immunogenetics Journal Issue: 4 Vol. 40; ISSN IMNGBK; ISSN 0093-7711
- Country of Publication:
- United States
- Language:
- English
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