A new DRB1*1202 allele (DRB1*12022) found in association with DQA1*0102 and DQB1*0602 in two Black narcoleptic subjects
- Stanford Univ. Blood Center, Palo Alto, CA (United States)
- Stanford Univ. Sleep Disorders Center, Palo Alto, CA (United States)
DQB1*0602 is a better genetic marker than DR2 for narcolepsy susceptibility across all ethnic groups; for instance, only 75% of African American narcoleptics are DR2+ compared with 96% DQB1*0602+. We studied DRB1 genes of DR2- but DQB1*0602+ African American patients with cataplexy and observed two with an unusual DR12, DQA1*0102, DQB1*0602 haplotype; a new allelic variant of DRB1*1202 has been designated DRB*12022. 8 refs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 75576
- Journal Information:
- Immunogenetics, Journal Name: Immunogenetics Journal Issue: 1 Vol. 41; ISSN 0093-7711; ISSN IMNGBK
- Country of Publication:
- United States
- Language:
- English
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