Genetic mapping of the LMP2 proteasome subunit gene to the BoLA class IIb region
- Univ. of Illinois, Champaign, IL (United States)
Recent identification of four tightly-linked genes within the class II region of the major histocompatibility complex (MHC) in humans and rodents has led to a better understanding of class I antigen processing mechanisms. Two of these genes, LMP2 and LMP7, encode subunits of a low molecular mass poypeptide (LMP) complex. Several observations suggest that the LMP complex may be the proteolytic system responsible for generating the size-restricted peptides required for MHC class I assembly. For example, the LMP complex is a large cytoplasmic structure that is antigenically and biochemically related to the proteasome, a proteolytic complex that mediates degradation of ubiquitinated substrates. Data regarding proteolytic specificity indicates that the LMP complex may specifically produce nonamers, the appropriate peptide size for class I binding. In addition, similar to all components of the class I assembly process, intra-MHC LMP genes are regulated by IFN{gamma}. 26 refs., 2 figs., 1 tab.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 75573
- Journal Information:
- Immunogenetics, Journal Name: Immunogenetics Journal Issue: 1 Vol. 41; ISSN 0093-7711; ISSN IMNGBK
- Country of Publication:
- United States
- Language:
- English
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