Immunologic response in vaccinated mice during long-term exposure to nitrogen dioxide

Journal Article · Wed Oct 01 04:00:00 EDT 1975 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(75)90085-7· OSTI ID:7365191

Ehrlich, R ^[1]; Silverstein, E; Maigetter, R; Fenters, J D; Gardner, D

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1. ITT Research Inst., Chicago

Swiss albino mice were continuously exposed to either 2 ppm NO/sub 2/, 0.5 ppm NO/sub 2/ with daily 1-hour peaks of 2 ppm NO/sub 2/, 5 days a week, or to filtered air. After a 12-week exposure the mice were vaccinated with A/sub 2//Taiwan influenza virus vaccine and the exposures to the various environmental conditions continued for an additional 28 weeks. At 2 weeks after vaccination, the serum neutralizing (SN) antibody titers and SN seroconversion rates were depressed to a various extent in mice exposed to NO/sub 2/. At 4 weeks after the vaccination and later, the SN antibody titers did not differ significantly among the various groups. Nonvaccinated mice exposed to NO/sub 2/ for 12 weeks showed a marked decrease in concentrations (mg/ml) of serum IgA, and an increase in serum IgM, IgG/sub 1/ and IgG/sub 2/ immunoglobulins. When concentrations of immunoglobulins were adjusted for age of mice after vaccination, a significant elevation was observed in serum IgM, IgG/sub 1/ and IgG/sub 2/ of mice exposed to NO/sub 2/ as compared to controls. During the 2-week period immediately following the vaccination, exposure to NO/sub 2/ appeared to be the predominant factor influencing the percentage concentration of the four serum immunoglobulins.

• OSTI ID: 7365191
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 10:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
AGGLUTININS
ANIMALS
ANTIBODIES
BIOLOGICAL EFFECTS
CHALCOGENIDES
COMPARATIVE EVALUATIONS
GLOBULINS
HEMAGGLUTININS
IMMUNE SERUMS
IMMUNOGLOBULINS
INFLUENZA VIRUSES
INHALATION
INHIBITION
INTAKE
MAMMALS
MICE
MICROORGANISMS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PARASITES
PROTEINS
RESPONSE MODIFYING FACTORS
RODENTS
VACCINES
VERTEBRATES
VIRUSES