Immunological alterations in the lungs of mice following ozone exposure: changes in immunoglobulin levels and antibody-containing cells

Journal Article · Sun Jul 01 04:00:00 EDT 1979 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1979.10667411· OSTI ID:5486696

Osebold, J W; Owens, S L; Zee, Y C; Dotson, W M; LaBarre, D D

Ozone was added to the air of environmental chambers containing specific pathogen-free mice. At levels of 0.5 and 0.8 ppM the oxidant was seen to have inflammatory effects, as shown by rising serum albumin levels in lung lavage fluid. Fluorescein conjugated anti-heavy chain sera were used to detect cells containing IgM, IgG, and IgA in measured lung areas termed Pulmonary Units. Antigenic stimuli occurred along rhe airways, with significant increases of IgA-containing cells in the bronchus-associated lymphoid tissue. The numbers of IgM- and IgG-containing cells did not increase. Immunodiffusion analyses for immunoglobulins in lung lavage fluid indicated increases of IgG/sub 1/, IgG/sub 2/, and IgA in lung secretions. The calculation of changing Ig/Alb ratios suggested that the IgA present was largely the result of local synthesis, while IgG molecules were mainly of serum origin. Possible sources of the antigenic stimuli to ozone-exposed lungs are discussed.

• Research Organization: Univ. of California, Davis
• OSTI ID: 5486696
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 34:4; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

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551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ALBUMINS
ANIMALS
ANTIBODIES
AROMATICS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BLOOD SERUM
BODY
CARBOXYLIC ACIDS
DOSE-RESPONSE RELATIONSHIPS
DYES
EXPOSURE CHAMBERS
FLUORESCEIN
GLOBULINS
HYDROXY ACIDS
HYDROXY COMPOUNDS
IMMUNE REACTIONS
IMMUNOGLOBULINS
IMMUNOLOGY
INHALATION
INTAKE
LAVAGE
LUNGS
MAMMALS
MICE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OZONE
PHENOLS
POLLUTION
POLYPHENOLS
PROTEINS
RESPIRATORY SYSTEM
RODENTS
SYNTHESIS
VERTEBRATES