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Experimental reorganization of the cerebellar cortex. V. Effects of early x-irradiation schedules that allow or prevent the acquisition of basket cells

Journal Article · · J. Comp. Neurol.; (United States)
In neonate and infant rats the area of the cerebellum was irradiated with different schedules of single or multiple doses of low-level X-ray. One set of schedules allowed the early recovery of the external germinal layer and the differentiation of all the postnatally-forming cell types while the other selectively prevented the acquisition of basket cells. The first schedule did not interfere with the development of normally oriented and arborizing Purkinje cells. The second schedule led to the growth of twisted and entwined stem dendrites even when, in association with the recovered granule cells, parallel fibers were present in the molecular layer together with Purkinje cell spiny branchlets. Evidence was presented that the alignment of Purkinje cell perikarya in a monolayer does not guarantee the normal growth of Purkinje cell stem dendrites which may be dependent on the presence of basket cells. The problem was discussed whether cell differentiation in the cerebellar cortex is governed by a chronological or sequential principle. (auth)
Research Organization:
Purdue Univ., Lafayette, IN
OSTI ID:
7365164
Journal Information:
J. Comp. Neurol.; (United States), Journal Name: J. Comp. Neurol.; (United States) Vol. 165:1; ISSN JCNEA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY
BRAIN
CELL DIFFERENTIATION
CENTRAL NERVOUS SYSTEM
CEREBELLUM
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
IRRADIATION
LOW DOSE IRRADIATION
MAMMALS
NERVOUS SYSTEM
ORGANS
RADIATION EFFECTS
RADIATIONS
RATS
RECOVERY
RODENTS
VERTEBRATES
X RADIATION