Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Effects of low-level x-irradiation on cat cerebella at different postnatal intervals. II. Changes in Purkinje cell morphology

Journal Article · · J. Comp. Neurol.; (United States)
;
The whole-head of infant kittens was irradiated with fractionated doses of 150 R and 200 R at different postnatal intervals. Experimental age conditions consisted of an irradiated newborn, 1-week, 2-week, 3-week, and a 4-week age condition while the age of sacrifice remained constant at 70 days. The molecular layer thickness was reduced by 47 percent in the newborn, 40 percent in the 1-week group, 17 percent in the 2-week group, 19 percent in the 3-week group and by 9 percent in the 4-week group. An evaluation of Golgi impregnated material revealed that the dendritic arborizations of Purkinje cells were consistently reduced the earlier the age at which radiation was begun. A reduction in spiny branchlets was seen in all of the experimental conditions. Climbing fibers were found to conform to the abnormal dendritic arborizations of the Purkinje cells, and were reduced in complexity in the early radiation treatment groups. This suggested that climbing fibers had no influence upon the dendritic growth pattern, but instead were under the influence of the Purkinje cell dendritic growth.
Research Organization:
Indiana State Univ., Terre Haute
OSTI ID:
7310811
Journal Information:
J. Comp. Neurol.; (United States), Journal Name: J. Comp. Neurol.; (United States) Vol. 171:1; ISSN JCNEA
Country of Publication:
United States
Language:
English

Similar Records

Effects of low-level x-irradiation on cat cerebella at different postnatal intervals. III. Changes in the morphology of interneurons in the molecular layer
Journal Article · Fri Dec 31 23:00:00 EST 1976 · J. Comp. Neurol.; (United States) · OSTI ID:7215296
Effects of lead on central nervous system development of the cat and rat
Thesis/Dissertation · Mon Dec 31 23:00:00 EST 1979 · OSTI ID:6208237
Experimental reorganization of the cerebellar cortex. VII. Effects of late x-irradiation schedules that interfere with cell acquisition after stellate cells are formed
Journal Article · Wed Dec 31 23:00:00 EST 1975 · J. Comp. Neurol.; (United States) · OSTI ID:7195062

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CATS
CENTRAL NERVOUS SYSTEM
CEREBELLUM
ELECTROMAGNETIC RADIATION
FRACTIONATED IRRADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MORPHOLOGICAL CHANGES
NERVE CELLS
NERVOUS SYSTEM
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
SOMATIC CELLS
VERTEBRATES
X RADIATION