Effects of low-level x-irradiation on cat cerebella at different postnatal intervals. III. Changes in the morphology of interneurons in the molecular layer

Journal Article · Sat Jan 01 04:00:00 EST 1977 · J. Comp. Neurol.; (United States)

DOI:https://doi.org/10.1002/cne.901710105· OSTI ID:7215296

Anderson, W J; Stromberg, M W

The whole head of infant kittens was irradiated with fractionated doses of 150 R and 200 R at different postnatal intervals. Experimental age conditions consisted of a newborn, 1-week, 2-week, 3-week, and a 4-week age condition while the age of sacrifice remained constant at 70 days. Going analysis revealed that the interneurons found in the molecular layer of the newborn, 1-week and 2-week condition were basket cells. Stellate cells were found in increasing numbers in the 3-week and 4-week conditions. Basket cells were found to occupy the entire molecular layer in the newborn and 1-week conditions resulting in an abnormal axonal plexus. The position of the basket cell soma was found to be in the same plane as its axonal projection. A hypothesis is presented to account for the decreased dendritic arborization and the increased length of the primary dendrite before branching, the ectopic basket cell and their abnormally directed dendritic growth, and the difference in behavioral deficits between the newborn and the 1-week conditions.

• Research Organization: Indiana State Univ., Terre Haute
• OSTI ID: 7215296
• Journal Information: J. Comp. Neurol.; (United States), Journal Name: J. Comp. Neurol.; (United States) Vol. 171:1; ISSN JCNEA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
BRAIN
CATS
CENTRAL NERVOUS SYSTEM
CEREBELLUM
ELECTROMAGNETIC RADIATION
FRACTIONATED IRRADIATION
HEAD
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MORPHOLOGICAL CHANGES
NERVE CELLS
NERVOUS SYSTEM
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
SOMATIC CELLS
VERTEBRATES
X RADIATION