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Effects of single and multifraction radiation courses on the mouse spinal cord

Journal Article · · Radiology; (United States)
OSTI ID:7364205
; ;
Thoraco-lumbar spinal cord segments of C3H mice were irradiated with 250 kVp x rays and the acute and late effects of several variables were compared: single and multifraction radiation courses; changes in the length of irradiated spinal cord; and multifraction studies in which three-week and three-month splits were compared to a continuous radiation course. A scoring system for assessing the degree of radiation-induced myelopathy was devised, using a scale ranging from 1.0 (loss of rear limb reflex extension) to 4.0 (paraplegia). A significant increase in severity of spinal cord radiation injury was noted when single doses were compared to equal doses given in 10 consecutive fractions. Increasing the irradiated segment from 6 to 12 mm was also associated with more severe and earlier radiation cord injury.
Research Organization:
Stanford Univ. Hospital, CA
OSTI ID:
7364205
Journal Information:
Radiology; (United States), Journal Name: Radiology; (United States) Vol. 119:3; ISSN RADLA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CENTRAL NERVOUS SYSTEM
COMPARATIVE EVALUATIONS
DELAYED RADIATION EFFECTS
DISEASES
EARLY RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
FRACTIONATED IRRADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
MYELITIS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RODENTS
SPINAL CORD
VERTEBRATES
X RADIATION