Combined effects of hyperthermia and ionizing radiation on the adult mouse spinal cord. [X Radiation]

Journal Article · Tue Nov 01 04:00:00 EST 1977 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574694· OSTI ID:5143623

Goffinet, D R; Choi, K Y; Brown, J M

Adult mouse spinal cord temperatures of 42/sup 0/C were maintained for over 60 min by immersing the intact thoraco-lumbar area in a 44/sup 0/C water bath. A scoring system which assessed both mild and severe radiation myelopathy was used. Single radiation doses to the thoraco-lumbar spinal cord immediately before or after localized hyperthermia were found to shorten the postirradiation latent period for both mild and severe myelitis when compared to control mice which received only spinal cord irradiation or heat 2 weeks prior to irradiation. Significantly lower doses of radiation produced severe myelitis in 50% of the mice (MD/sub 50/) at both 6 and 9 to 12 months postirradiation in the two groups in which heat and radiation were given almost together as compared to the MD/sub 50/'s for control mice (irradiation alone or heat and radiation separated by 2 weeks). Possible mechanisms for this apparent hyperthermic spinal cord radiosensitization are discussed.

• Research Organization: Stanford Univ. Medical Center, CT
• OSTI ID: 5143623
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 72:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY TEMPERATURE
CENTRAL NERVOUS SYSTEM
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
HYPERTHERMIA
IONIZING RADIATIONS
MAMMALS
MICE
MYELITIS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
SPINAL CORD
VERTEBRATES
X RADIATION