Control of tissue manganese: initial absence and sudden emergence of excretion in the neonatal mouse. [/sup 54/Mn tracer]
Journal Article
·
· Am. J. Physiol.; (United States)
OSTI ID:7361103
All adult animals and humans tested up to this time have controlled their tissue manganese concentrations by controlling primarily the rate of the metal's excretion. In sharp contrast, neonatal mice did not excrete manganese for the first 17 to 18 days of life, although absorption of the natural /sup 55/Mn as well as distribution, tissue accumulation, and mitochondrial accumulation of the radioactive /sup 54/Mn were vigorous. This suggested an initially avid accumulation of this essential micronutrient, supplied in scarce traces in mouse milk (54 ng/ml) by mothers consuming very much higher dietary concentrations (55,000 ng/g). The tissue accumulation was demonstrated analytically and was particularly impressive in the brain, which can be susceptible to both manganese poisoning and deficiency. (auth)
- Research Organization:
- Brookhaven National Lab., Upton, NY
- OSTI ID:
- 7361103
- Journal Information:
- Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 229:4; ISSN AJPHA
- Country of Publication:
- United States
- Language:
- English
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