Interactions between manganese and brain dopamine. [Mice, rats]
Journal Article
·
· Med. Clin. North Am.; (United States)
The neonatal mouse was shown to share with the neonatal rat and kitten an initial inability to excrete the essential element manganese. In the mouse, it was shown that the blood-brain barrier against the metal is much less efficient postnatally than in the mature mouse. Varying the dietary concentration of manganese consumed by lactating mothers showed that the manganese concentration in the mother's milk tended to rise with that in the diet. The tissue manganese concentrations of both mothers and offspring, when plotted against the concentration of the metal in the diet, described straight lines with very low slopes: for relatively small increments of tissue concentration one needed large increments of dietary manganese. Only when massive dietary manganese levels were reached was there a sudden, marked increase in the tissues of both mothers and offspring. Under such dietary conditions, the offspring showed premature initiation of the metal's excretion. In view of the effects of chronic manganese poisoning on cerebral dopamine, appropriate measurements were initiated which, for the moment, have shown the following: that adult mice consuming diets containing massive amounts of manganese developed statistically significant elevations of cerebral dopamine.
- Research Organization:
- Brookhaven National Lab., Upton, NY
- OSTI ID:
- 7211839
- Journal Information:
- Med. Clin. North Am.; (United States), Journal Name: Med. Clin. North Am.; (United States) Vol. 60:4; ISSN MCNAA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200* -- Biochemistry
550500 -- Metabolism
59 BASIC BIOLOGICAL SCIENCES
AGE DEPENDENCE
AMINES
ANIMALS
AROMATICS
BIOCHEMISTRY
BLOOD-BRAIN BARRIER
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHEMISTRY
CLEARANCE
DIET
DISTRIBUTION
DOPAMINE
DRUGS
ELEMENTS
EXCRETION
HYDROXY COMPOUNDS
LACTATION
MAMMALS
MANGANESE
METABOLISM
METALS
MICE
NEONATES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
RATS
RODENTS
SYMPATHOMIMETICS
TISSUE DISTRIBUTION
TRANSITION ELEMENTS
VERTEBRATES
550500 -- Metabolism
59 BASIC BIOLOGICAL SCIENCES
AGE DEPENDENCE
AMINES
ANIMALS
AROMATICS
BIOCHEMISTRY
BLOOD-BRAIN BARRIER
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHEMISTRY
CLEARANCE
DIET
DISTRIBUTION
DOPAMINE
DRUGS
ELEMENTS
EXCRETION
HYDROXY COMPOUNDS
LACTATION
MAMMALS
MANGANESE
METABOLISM
METALS
MICE
NEONATES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
RATS
RODENTS
SYMPATHOMIMETICS
TISSUE DISTRIBUTION
TRANSITION ELEMENTS
VERTEBRATES