Renal function in the rat following irradiation

Journal Article · Thu Jul 01 04:00:00 EDT 1976 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574498· OSTI ID:7356493

Chauser, B M; Hudson, F R; Law, M P

Renal function in the rat has been measured after irradiation of the left kidney with single doses of 1000, 2000, or 3000 rad of 250 kVp x rays. Effective renal plasma flow during 6 months postirradiation was estimated using (/sup 123/I)hippuran and a gamma-camera with a pinhole collimator. Major renal failure was observed at 18 weeks after 2000 rad and slightly earlier after 3000 rad. The deposition of collagen was measured by estimation of the hydroxyproline content. This was increased in irradiated kidneys 20 weeks after doses of 2000 and 3000 rad. The relationship between kidney function and fibrosis is discussed.

• Research Organization: Hammersmith Hospital, London
• OSTI ID: 7356493
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 67:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COLLAGEN
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
LOCAL IRRADIATION
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHYSIOLOGY
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RATS
RODENTS
SCLEROPROTEINS
TRACER TECHNIQUES
VERTEBRATES
X RADIATION