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Interaction of cisplatin and x-rays in rat kidney

Journal Article · · NCI Monogr.; (United States)
OSTI ID:7195027
; ;
Cisplatin was administered as a single iv dose of 5 mg/kg in WAG/Rij female rats at intervals of 7 days or 30 minutes before or 7 days after graded irradiation of the left kidney. The unirradiated right kidney was removed 4 weeks after the x-ray treatment. Kidney function was determined by measuring urine osmolality and plasma urea. The kidney function parameters did not change measurably in animals treated with cisplatin alone. Only differences in urine osmolality were observed between the groups that received combined treatment or irradiation only. Long-term renal fibrosis was assessed by measuring the hydroxyproline content. Significant increases in renal hydroxyproline content were observed in animals receiving treatment with cisplatin either 7 days before or 7 days after irradiation, compared with animals receiving irradiation alone.
Research Organization:
Radiobiological Institute TNO, Rijswijk (The Netherlands)
OSTI ID:
7195027
Journal Information:
NCI Monogr.; (United States), Journal Name: NCI Monogr.; (United States) Vol. 6; ISSN NCIME
Country of Publication:
United States
Language:
English

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Related Subjects

550600 -- Medicine
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMIDES
AMINES
AMINO ACIDS
ANIMALS
ANTINEOPLASTIC DRUGS
AZOLES
BODY
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACIDS
COMBINED THERAPY
DISEASES
DRUGS
DYNAMIC FUNCTION STUDIES
ELECTROMAGNETIC RADIATION
FRACTIONATED IRRADIATION
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROXY ACIDS
HYDROXYPROLINE
IONIZING RADIATIONS
IRRADIATION
KIDNEYS
MAMMALS
NEOPLASMS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRROLES
PYRROLIDINES
RADIATIONS
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
THERAPY
UREA
VERTEBRATES
X RADIATION