Can x-rays be used to increase litter size in the mouse

Journal Article · Sun Feb 01 04:00:00 EST 1976 · Biol. Bull.; (United States)

DOI:https://doi.org/10.2307/1540592· OSTI ID:7354853

Rugh, R

The average litter size for normal CF/sub 1/ mice is close to 10.5, varying in the experiments from 9.75 to 11.73. Separate groups of controls were provided for each of the three major experiments. Resorptions were found even among the control groups, with an average of 1.5 percent. Among litters from matings immediately after (whole-body) x radiation from 10 to 200r, the variations in resorptions over exposure levels was minimal, while variation in average litter size was within the range of normal experience for these mice. Even among mice mated one week after exposure the differences in litter sizes were small and the statistical significance tenuous. It was found that even a maximum exposure of 200R altered neither the resorption rate or production of anomalies, nor induced any significant increase in litter size. When the various phases of the estrous cycle were segregated for irradiation to 100R it was found that those in estrus showed somewhat smaller mean litter size than those which were x irradiated during diestrus or metestrus. However, when compared with the control group, which probably included all phases of the estrous cycle, there was no statistically significant change. On the basis of the study of some 8000 offspring, there is no evidence of significant change in ova production following whole-body x radiation from 10R to 200R of mature CF/sub 1/ female mice, and no evidence of superovulation. (auth)

• Research Organization: Dept. of Health, Education, and Welfare, Rockville, MD
• OSTI ID: 7354853
• Journal Information: Biol. Bull.; (United States), Journal Name: Biol. Bull.; (United States) Vol. 150:1; ISSN BIBUA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
ESTROUS CYCLE
EXTERNAL IRRADIATION
GAMETES
GERM CELLS
IONIZING RADIATIONS
IRRADIATION
LITTER SIZE
MAMMALS
MICE
OVA
OVULATION
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION