Fluctuations in selenium status during the female rat estrous cycle

Conference · Sun Mar 10 23:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5264381

Cha, C; Smith, A M; Kimura, R E ^[1]

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1. Univ. of Utah, Salt Lake City (United States) Ohio State Univ., Columbus (United States)

A suggested relationship between selenium (Se) status and sex hormones is based on sex-linked differences in Se status of the liver and dramatic changes in Se status during pregnancy. The effect of estrous cycle hormone fluctuation on Se status was studied in the chronically-catheterized rat model. Se status, measured as plasma and RBC Se and glutathione peroxidase activity (GPx), was assessed at each stage of the 4-day estrous cycle. Stages, determined by cytological exam of vaginal smears, were estrus (E), metestrus (ME), diestrus (DE), and proestrus (PE). Five rats fed a 0.1 ppm Se diet, were catheterized at the abdominal aorta, allowing serial blood draws under nonstressful conditions. At least three blood samples per rat were collected daily for two consecutive cycles. Plasma Se during PE was significantly greater than that at E, ME, or DE. Peak plasma Se occurred at 1,000 hr PE. Peak estrogen and progesterone levels have been reported to occur later in PE. Peak plasma occurred during ME and early PE. A significant decrease in plasma GPx during late PE corresponds with reported peaks in estrogen and progesterone. There were no significant differences in RBC Se or GPx during the estrous cycle. The results of this study suggest that changes in plasma Se and GPx during the estrous cycle may precede similar fluctuations in estrogen and progesterone.

• OSTI ID: 5264381
• Report Number(s): CONF-9104107--
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Vol. 5:4; ISSN 0892-6638; ISSN FAJOE
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BLOOD PLASMA
BODY FLUIDS
ELEMENTS
ENZYME ACTIVITY
ENZYMES
ERYTHROCYTES
ESTROGENS
ESTROUS CYCLE
HORMONES
KETONES
MAMMALS
MATERIALS
METABOLISM
ORGANIC COMPOUNDS
OXIDOREDUCTASES
PEROXIDASES
PREGNANCY
PREGNANES
PROGESTERONE
PROTEINS
RATS
RODENTS
SELENIUM
SEMIMETALS
STEROID HORMONES
STEROIDS
SYNTHESIS
VERTEBRATES