Enhanced pulmonary toxicity with bleomycin and radiotherapy in oat cell lung cancer

Journal Article · Sat May 01 04:00:00 EDT 1976 · Cancer; (United States)

DOI:https://doi.org/10.1002/1097-0142(197605)37:5<2414::AID-CNCR2820370533>3.0.CO;2-J· OSTI ID:7352686

Einhorn, L; Krause, M; Hornback, N; Furnas, B

In a recently completed study, combination chemotherapy consisting of bleomycin, adriamycin, cyclophosphamide, and vincristine was given to 29 patients with oat cell lung cancer. There were no cases of pulmonary fibrosis in these 29 patients. Although several of these patients had prior radiotherapy, none had concomitant radiotherapy and chemotherapy. This same four-drug chemotherapy regimen was combined with concomitant radiotherapy in 13 patients with oat cell lung cancer. There were three cases of fatal pulmonary fibrosis and two other cases of clinically significant pulmonary fibrosis. All five cases of pulmonary fibrosis occurred several weeks after completion of a six-week course of bleomycin (total dosage 90 units). It is concluded that bleomycin cannot be safely administered while patients are receiving radiotherapy of the lung.

• Research Organization: Indiana Univ., Indianapolis
• OSTI ID: 7352686
• Journal Information: Cancer; (United States), Journal Name: Cancer; (United States) Vol. 37:5; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
BLEOMYCIN
BODY
CHEMOTHERAPY
DISEASES
DRUGS
ENDOXAN
FIBROSIS
LUNGS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
SIDE EFFECTS
THERAPY
TOXICITY