Comparison of inulin, iothalamate, and /sup 99m/Tc-DTPA for measurement of glomerular filtration rate

Journal Article · Thu Apr 01 04:00:00 EST 1976 · J. Nucl. Med.; (United States)

OSTI ID:7352650

Barbour, G L; Crumb, C K; Boyd, C M; Reeves, R D; Rastogi, S P; Patterson, R M

Clearances of inulin, /sup 125/I-iothalamate, and /sup 99m/Tc-Sn-DTPA were measured simultaneously in five mongrel dogs exhibiting a wide range of glomerular filtration rates (GFR). Standard constant-infusion inulin clearance was compared to radionuclide clearances after subcutaneous injection of the emitters mixed with aqueous epinephrine. All three substances were found to have virtually identical clearances. The accuracy, accessibility, low cost, low radiation hazard, and short half-life of /sup 99m/Tc-Sn-DTPA make it an excellent substance for measuring GFR. The subcutaneous technique offers an accuracy comparable to the more difficult constant-infusion method. (auth)

• Research Organization: Veterans Administration Hospital, Little Rock, AR
• OSTI ID: 7352650
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 17:4; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COMPLEXES
DAYS LIVING RADIOISOTOPES
DOGS
DRUGS
DTPA
ELECTRON CAPTURE RADIOISOTOPES
EXCRETION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INULIN
IODINE 125
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
POLYSACCHARIDES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPROTECTIVE SUBSTANCES
RENAL CLEARANCE
RESPONSE MODIFYING FACTORS
SACCHARIDES
TECHNETIUM 99
TECHNETIUM ISOTOPES
TIN COMPLEXES
VERTEBRATES
YEARS LIVING RADIOISOTOPES