Carcinoma of the nasopharynx; eighteen years' experience with megavoltage radiation therapy

Conference · Tue Jun 01 04:00:00 EDT 1976 · Cancer; (United States)

OSTI ID:7349023

Hoppe, R T; Goffinet, D R; Bagshaw, M A

From 1956 through 1973, 82 patients with carcinoma of the nasopharynx received high dose megavoltage radiation therapy at Stanford University. The actuarial disease-free (NED) survival was 62 percent at 5 years and 56 percent at 10 years. The NED survivals at 5 years for patients with T1, T2, and T3 lesions were 76 percent, 68 percent, and 55 percent, respectively. No T4 patients were salvaged, but two of 10 patients who presented with cranial nerve dysfunction were long-term survivors. The degree of nodal involvement also had prognostic significance. Involved lymph nodes were successfully controlled in all instances when doses of at least 6500 rads were given. Initial treatment failed in 32 patients. In 24 (75 percent) this occurred within 18 months. Thirteen patients with initial recurrences in head and neck sites were retreated and three remain alive. Survival after retreatment ranged from 2 months to 10 years, with a median of 16 months. Although nearly one-third (6/17) of the patients with local recurrences had initial T1 or T2 lesions, there have been no failures in patients treated for these early stages in the last 7 years. This may be attributed to the use of larger treatment fields. Likewise, prophylactic irradiation of the neck was always successful in preventing nodal disease if the primary site was controlled.

• Research Organization: Stanford Univ. Medical Center, CA
• OSTI ID: 7349023
• Conference Information: Journal Name: Cancer; (United States) Journal Volume: 37:6
• Country of Publication: United States
• Language: English

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560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AUDITORY ORGANS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE JOINTS
CARCINOMAS
DIGESTIVE SYSTEM
DISEASES
FIBROSIS
GLANDS
MEDICINE
NECROSIS
NEOPLASMS
NUCLEAR MEDICINE
ORAL CAVITY
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PHARYNX
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
SALIVARY GLANDS
SENSE ORGANS
SIDE EFFECTS
SKELETON
TEETH
THERAPY