Combinations of hyperthermia (40/sup 0/, 45/sup 0/C) with radiation. [X radiation]

Journal Article · Mon Nov 01 04:00:00 EST 1976 · Radiology; (United States)

OSTI ID:7344892

Henle, K J; Leeper, D B

Incubation of Chinese hamster cells at an elevated but sublethal temperature between fractions of radiation and/or pulses of hyperthermia at 45/sup 0/C strongly modified the effectiveness of cell killing. Increasing the incubation temperature from 37 to 40/sup 0/C between fractions of hyperthermia at 45/sup 0/C followed by radiation substantially enhanced cell killing; while the opposite sequence (radiation ..-->.. incubation at 40/sup 0/C ..-->.. hyperthermia at 45/sup 0/C) resulted in less effective cell killing than would have been expected from the independent interaction of hyperthermia and radiation alone. This suggests the use of short pulses of localized hyperthermia in the presence of physiologically tolerable fever followed by irradiation as one approach to the utilization of hyperthermia in cancer therapy.

• Research Organization: Thomas Jefferson Univ., Philadelphia
• OSTI ID: 7344892
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 121:2; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY TEMPERATURE
CELL KILLING
ELECTROMAGNETIC RADIATION
HAMSTERS
HYPERTHERMIA
IONIZING RADIATIONS
MAMMALS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RODENTS
TEMPERATURE EFFECTS
VERTEBRATES
X RADIATION