Differential cytotoxic effects of hyperthermia below and above 43/sup 0/C alone or combined with x irradiation
Journal Article
·
· Radiat. Res.; (United States)
The effect of hyperthermia alone or combined with X irradiation on the proliferative capacity of CHO cells was studied for temperatures between 41 and 46/sup 0/C. For heat treatments in the range 41-43/sup 0/C or 43-46/sup 0/C, the Arrhenius plot yielded an inactivation energy of 417 +/- 28 and 167 +/- 16 kcal/mole, respectively. Hyperthermia at 42 and 45/sup 0/C, which by itself killed 10% of the cells, was combined with single X-ray doses ranging up to 7 Gy or with fractionated irradiation with two doses of 3 Gy. A mathematical description was developed to determine the effect of hyperthermia on repair of sublethal damage. At 37/sup 0/C sublethal damage was repaired with a half-time of 43.3 min. At 42/sup 0/C, hyperthermia accelerated the fixation of damage and enhanced repair of remaining sublethal damage, reducing the half-time to 19.3 min. In contrast, hyperthermia at 45/sup 0/C did not affect fixation of damage but depressed the rate of repair of sublethal damage, thus increasing the half-time to 83 min.
- Research Organization:
- Univ. of Hamburg, Federal Republic of Germany
- OSTI ID:
- 5678036
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 88:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560201 -- Thermal Effects-- Cells-- (-1987)
560205 -- Thermal Effects-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY TEMPERATURE
CELL PROLIFERATION
COMPARATIVE EVALUATIONS
DAMAGE
DOSES
ELECTROMAGNETIC RADIATION
HAMSTERS
HYPERTHERMIA
IONIZING RADIATIONS
MAMMALS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RODENTS
TEMPERATURE EFFECTS
TOXICITY
VERTEBRATES
X RADIATION
560201 -- Thermal Effects-- Cells-- (-1987)
560205 -- Thermal Effects-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY TEMPERATURE
CELL PROLIFERATION
COMPARATIVE EVALUATIONS
DAMAGE
DOSES
ELECTROMAGNETIC RADIATION
HAMSTERS
HYPERTHERMIA
IONIZING RADIATIONS
MAMMALS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RODENTS
TEMPERATURE EFFECTS
TOXICITY
VERTEBRATES
X RADIATION