Effects of whole-body. gamma. -irradiation on the biosynthesis of certain serum proteins. Final report, November 29, 1967--June 30, 1976. [Rats]

Technical Report · Wed Jun 30 04:00:00 EDT 1976

DOI:https://doi.org/10.2172/7343043· OSTI ID:7343043

Neuhaus, O W

Whole-body exposure of rats to ionizing radiations yielded an increased incorporation of labeled amino acids into serum albumin in in vivo studies suggesting a stimulation of biosynthesis. Actually this may have been caused by an elevated hepatic transport of labeled amino acids (see below). A suppressed biosynthesis of albumin was observed when the experiments were performed in vitro using liver microsomes. Impaired biosynthesis appeared to be caused by a reduced mRNA production. Irradiation stimulated the biosynthesis of acute-phase plasma proteins (stress response) and inhibited the excretion of ..cap alpha../sub 2u/-globulin, the sex-dependent protein of the adult male rat. Exposure of rats to ..gamma..-rays stimulated amino acid transport into the liver. This process which is Na/sup +/ and energy-dependent was studied with ..cap alpha..-aminoisobutyric acid, cycloleucine, and L-methionine among others. After irradiation the serum glucagon and insulin, as well as hepatic cAMP levels, were elevated. Amino acid transport may be an important factor in controlling the increased gluconeogenesis and glycogenesis observed in rats following whole-body irradiation.

• Research Organization: South Dakota Univ., Vermillion (USA). Dept. of Biochemistry
• OSTI ID: 7343043
• Report Number(s): COO-1754-18
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALBUMINS
AMINO ACIDS
AMP
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
BODY
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CLEARANCE
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
EXCRETION
GAMMA RADIATION
GLANDS
GLOBULINS
GLUCAGON
HORMONES
INSULIN
IONIZING RADIATIONS
LIVER
MAMMALS
MICROSOMES
NUCLEIC ACIDS
NUCLEOTIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
PEPTIDE HORMONES
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIATION EFFECTS
RADIATIONS
RATS
RNA
RODENTS
SYNTHESIS
VERTEBRATES