Hormonal control of amino acid transport in the liver of rats exposed to whole-body. gamma. -irradiation

Journal Article · Wed Feb 01 04:00:00 EST 1978 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574827· OSTI ID:7286951

Kilberg, M S; Neuhaus, O W

Whole-body exposure of rats to ..gamma.. rays led to a degeneration of tissue proteins and a concomitant elevation in blood amino acids. Simultaneously there was a stimulated uptake of amino acids by the liver and a state of gluconeogenesis and glycogenesis. It has now been established that these events were accompanied by increases in both blood glucagon and insulin levels. Growth hormone and corticosterone were not affected. Although both glucagon and insulin stimulate amino acid transport, the former was primarily responsible for the elevated transport in the liver following whole-body irradiation. The primary role of glucagon was demonstrated by the radiation-induced uptake of N-methyl ..cap alpha..-aminoisobutyric acid, a model amino acid whose hepatic transport was previously shown to be affected by glucagon and not by insulin. Confirmatory evidence was obtained by showing that exogenous insulin actually inhibited the radiation-induced uptake of ..cap alpha..-aminoisobutyric acid and N-methyl ..cap alpha..-aminoisobutyric acid by the isolated perfused liver. Furthermore, the radiation syndrome was accompanied by elevated hepatic concentrations of cyclic AMP.

• Research Organization: Univ. of South Dakota School of Medicine, Vermillion
• OSTI ID: 7286951
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 73:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBOXYLIC ACIDS
CESIUM 137
CESIUM ISOTOPES
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GAMMA RADIATION
GLANDS
GLUCAGON
HORMONES
INSULIN
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
LIVER
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
UPTAKE
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES