Inborn anemias in mice. Comprehensive progress report to accompany twenty-first renewal proposal, 1 May 1973--30 April 1976
Progress is reported on the delineation of inborn anemias of the laboratory mouse, carried out by preparation of genetically homogeneous stocks segregating only for anemia-producing genes; by descriptions of each condition at all stages in the life history; by determination of tissue-sites of primary gene action through transplantation and parabiosis experiments; by analysis of reactions of normal and anemic mice to a variety of stressful stimuli, including x-irradiation and hypoxia; and by histological and biochemical study of normal vs. abnormal blood-forming tissue. At present 12 single-gene induced anemias are known in the mouse, plus one with multifactorial inheritance.
- Research Organization:
- Jackson Lab., Bar Harbor, Maine (USA)
- OSTI ID:
- 7340519
- Report Number(s):
- COO-3264-13
- Country of Publication:
- United States
- Language:
- English
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