Radioimmunoassay for glyburide in human serum. [Sulfonylurea; /sup 14/C and /sup 125/I]
Journal Article
·
· Anal. Lett.; (United States)
A radioimmunoassay (RIA) has been developed to measure nanogram amounts of drug-related materials in human serum, after oral administration of 1.25, 2.5, 3.75 or 5.0 mg glyburide, G, Micronase, a sulfonylurea. Of the compounds tested, only the known hydroxy metabolites of G cross-reacted significantly. Recoveries were quantitative (100.6 percent). In normal human volunteers, peak serum drug concentrations were observed at 4.3 +- 1.4 hrs (S.D., M = 32).
- Research Organization:
- Upjohn Co., Kalamazoo, MI
- OSTI ID:
- 7339212
- Journal Information:
- Anal. Lett.; (United States), Vol. 9:7
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
DRUGS
RADIOIMMUNOASSAY
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ANIMAL CELLS
ANTIBODIES
BLOOD SERUM
CARBON 14
CHEMICAL REACTION KINETICS
IODINE 125
LABELLING
SYNTHESIS
TRACE AMOUNTS
TRACER TECHNIQUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBON ISOTOPES
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-EVEN NUCLEI
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LIGHT NUCLEI
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
RADIOASSAY
RADIOISOTOPES
REACTION KINETICS
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
DRUGS
RADIOIMMUNOASSAY
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ANIMAL CELLS
ANTIBODIES
BLOOD SERUM
CARBON 14
CHEMICAL REACTION KINETICS
IODINE 125
LABELLING
SYNTHESIS
TRACE AMOUNTS
TRACER TECHNIQUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBON ISOTOPES
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-EVEN NUCLEI
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LIGHT NUCLEI
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
RADIOASSAY
RADIOISOTOPES
REACTION KINETICS
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials