Selective protection of normal tissues by irradiation of tumor-bearing mice in hypoxic hypoxia. [Gamma radiation]

Journal Article · Wed Sep 01 04:00:00 EDT 1976 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574341· OSTI ID:7333848

Yarmonenko, S P; Wainson, A A; Bereznova, L I; Krimker, V M; Ovakimov, V G; Petrosian, E P; Shmakova, N L

The possibility of selective protection of normal tissues was demonstrated when mice with solid tumors were irradiated in an atmosphere of 95 percent N/sub 2/ and 5 percent O/sub 2/. Irradiation of animals in this gas mixture increased their survival with a dose-modifying factor (DMF) = 2.5, decreased the number of cells with chromosomal aberration in bone marrow (DMF, 2) and the degree of hair follicle damage (DMF, 1.6). The protective effect of hypoxia drastically diminished 40 min after its application. Local irradiation of allogeneic tumors under hypoxic conditions, on the other hand, resulted in an increased rate of their regression in comparison with irradiation in air. The mechanism of the observed phenomenon is under investigation.

• Research Organization: Oncology Research Center, Moscow
• OSTI ID: 7333848
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 67:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANOXIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DISEASES
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
IONIZING RADIATIONS
MAMMALS
MICE
NEOPLASMS
RADIATION EFFECTS
RADIATION PROTECTION
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
VERTEBRATES