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Cysteamine protection against lethal and growth-inhibiting effects of prenatal x and gamma irradiation

Journal Article · · Teratology; (United States)
Exposure of pregnant rats to gamma radiation on day 16 of gestation produced nearly double the number of neo- and postnatal offspring deaths as did x irradiation. Dose level (185 R), dose rate (10-12 R/minute), and distance from the source were the same in both groups. Cysteamine given prenatally prior to either gamma or x irradiation significantly decreased mortality. In the gamma-irradiated group the mortality rate remained significantly higher than in the control group, but in the x-irradiated group it was reduced to the control level by pretreatment with cysteamine. Cysteamine given to pregnant rats immediately following gamma irradiation had no effect on offspring mortality.
Research Organization:
Univ. of Detroit
OSTI ID:
7332313
Journal Information:
Teratology; (United States), Journal Name: Teratology; (United States) Vol. 3:4; ISSN TJADA
Country of Publication:
United States
Language:
English