The Effect of Cysteamine on the Survival of Foetal Germ Cells after Irradiation

Journal Article · Sat Dec 31 23:00:00 EST 1960 · International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine

DOI:https://doi.org/10.1080/09553006114550791· OSTI ID:4820082

Starkie, Carol M.

The abdomen of pregnant female rats was x irradiated between the 17th and 21st day of gestation with doses ranging between 50 and 150 r. The male offspring were killed 25 days after birth and their testes examined histologically. The results indicate that the extent of testicular damage (proportion of seminiferous tubules classified as normal, regenerating, and sterile) depends both on the dose of irradiation and the foetal age at the time of exposure. Pre-treatment of the pregnant rats with cysteamine shortly before irradiation partially inhibits the deleterious effect of irradiation on the testes of the offspring.

• Research Organization: The University, Birmingham, Eng.
• Sponsoring Organization: USDOE
• NSA Number: NSA-16-001632
• OSTI ID: 4820082
• Journal Information: International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Journal Name: International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine Journal Issue: 6 Vol. 3; ISSN 0020-7616
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
BIOLOGY AND MEDICINE
CYSTEINE
FETUSES
GONADS
RADIATION DOSES
RADIATION INJURIES
RADIATION PROTECTION
RATS
X RADIATION