Chemical formation of excited states during hydroxylation of the carcinogenic hydrocarbon benzo(. cap alpha. )pyrene by liver microsomes
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
It was verified that the enzymatic hydroxylation of carcinogenic aromatic hydrocarbons produces product molecules in electronically excited states. Introduction of the carcinogen benzo(..cap alpha..)pyrene into liver microsomes from 3-methylcholanthrene-induced rats results in a significant chemiluminescence which is shown for the first time to be correlated with the enzymatic hydroxylation of the parent carcinogen. The kinetics of the chemiluminescence implicate the intermediate epoxide as the precursor to the excited state product molecules.
- Research Organization:
- Johns Hopkins Univ., Baltimore
- OSTI ID:
- 7328009
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 70:3; ISSN BBRCA
- Country of Publication:
- United States
- Language:
- English
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Journal Article
·
Mon May 01 00:00:00 EDT 1978
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·
OSTI ID:6789428
Chemical production of excited states. Chemiluminescence of carcinoginic hydrocarbons accompanying their metabolic hydroxylation and a proposal for common active site geometries for hydroxylation
Conference
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Thu Sep 23 00:00:00 EDT 1976
· J. Phys. Chem.; (United States)
·
OSTI ID:7128339
Specificity of chemiluminescence in the metabolism of benzo(a)pyrene to its carcinogenic diol epoxide
Journal Article
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Sat Jan 31 23:00:00 EST 1981
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
·
OSTI ID:6503517
Related Subjects
550200 -- Biochemistry
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZOPYRENE
BIOLOGICAL EFFECTS
BODY
CELL CONSTITUENTS
CHEMICAL REACTIONS
CHEMILUMINESCENCE
CONDENSED AROMATICS
DIGESTIVE SYSTEM
ENERGY LEVELS
ENZYMES
EPOXIDES
EXCITED STATES
GLANDS
HYDROCARBONS
HYDROXYLATION
LIVER
LUMINESCENCE
MAMMALS
MICROSOMES
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANOIDS
ORGANS
RATS
RODENTS
SYNTHESIS
VERTEBRATES
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZOPYRENE
BIOLOGICAL EFFECTS
BODY
CELL CONSTITUENTS
CHEMICAL REACTIONS
CHEMILUMINESCENCE
CONDENSED AROMATICS
DIGESTIVE SYSTEM
ENERGY LEVELS
ENZYMES
EPOXIDES
EXCITED STATES
GLANDS
HYDROCARBONS
HYDROXYLATION
LIVER
LUMINESCENCE
MAMMALS
MICROSOMES
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANOIDS
ORGANS
RATS
RODENTS
SYNTHESIS
VERTEBRATES