Radiation sensitization of bacterial spores by cis-dichlorodiammineplatinum(II). [Bacillus megaterium]
Journal Article
·
· Radiat. Res.; (United States)
The x irradiation of B. megaterium spores in aqueous suspension in the presence of cis-dichlorodiammineplatinum(II) (CPCA) results in biphasic survival curves showing pronounced increases in radiation sensitivity in N/sub 2/ , O/sub 2/, and in N/sub 2/O in the low-dose portion of the response. In N/sub 2/, the degree of CPCA-induced sensitization fully equals that due to O/sub 2/ alone. In the presence of O/sub 2/ and N/sub 2/O, the added component of sensitization is half that obtained under N/sub 2/ saturation. Additional results are also obtained in the presence of hydroxyl radical scavengers, and in the presence of N/sub 2/O. These results are additionally significant considering that CPCA has been successfully used in animal studies as an antitumor drug.
- Research Organization:
- Univ. of Texas, Austin
- OSTI ID:
- 7324034
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 68:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Radiation Sensitivity of Bacillus megaterium Spores in the Presence of Co(III) Complexes
Radiation-induced DNA damage and lethality in E. coli as modified by the antitumor agent cis-dichlorodiammineplatinum(II)
OXYGEN AND NITRIC OXIDE AS MODIFIERS OF RADIATION INJURY IN SPORES OF BACILLUS MEGATERIUM
Journal Article
·
Tue Jul 01 00:00:00 EDT 1975
· Radiation Research
·
OSTI ID:4157785
Radiation-induced DNA damage and lethality in E. coli as modified by the antitumor agent cis-dichlorodiammineplatinum(II)
Journal Article
·
Mon Aug 01 00:00:00 EDT 1977
· Radiat. Res.; (United States)
·
OSTI ID:7282263
OXYGEN AND NITRIC OXIDE AS MODIFIERS OF RADIATION INJURY IN SPORES OF BACILLUS MEGATERIUM
Journal Article
·
Fri Jul 01 00:00:00 EDT 1960
· Proc. Natl. Acad. Sci. U.S.
·
OSTI ID:4178883
Related Subjects
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACILLUS
BACILLUS MEGATERIUM
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHALCOGENIDES
CRYOGENIC FLUIDS
ELECTROMAGNETIC RADIATION
ELEMENTS
FLUIDS
IONIZING RADIATIONS
MICROORGANISMS
NITROGEN
NITROGEN COMPOUNDS
NITROGEN OXIDES
NONMETALS
OXIDES
OXYGEN
OXYGEN COMPOUNDS
PLATINUM COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
SPORES
SURVIVAL CURVES
TRANSITION ELEMENT COMPOUNDS
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACILLUS
BACILLUS MEGATERIUM
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHALCOGENIDES
CRYOGENIC FLUIDS
ELECTROMAGNETIC RADIATION
ELEMENTS
FLUIDS
IONIZING RADIATIONS
MICROORGANISMS
NITROGEN
NITROGEN COMPOUNDS
NITROGEN OXIDES
NONMETALS
OXIDES
OXYGEN
OXYGEN COMPOUNDS
PLATINUM COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
SPORES
SURVIVAL CURVES
TRANSITION ELEMENT COMPOUNDS
X RADIATION