Effects of carbon disulfide and FLA-63 on operant behavior in pigeons
Journal Article
·
· J. Pharmacol. Exp. Ther.; (United States)
OSTI ID:7317422
Carbon disulfide (CS/sub 2/) and FLA-63 (bis(4-methyl-1-homopiperazinylthiocarbonyl)disulfide) were studied in pigeons working on a differential-reinforcement-of low-rates or a multiple fixed-interval fixed-ratio schedule of food reinforcement. Response rates on both schedules decreased after 8-hour exposures to CS/sub 2/ (3 mg/l) or administration of FLA-63 (40 and 80 mg/kg). The effects of two successive 8-hour exposures to CS/sub 2/ were cumulative and ten successive 4-hour exposures produced changes in differential-reinforcement-of-low-rates performance resembling those following acute exposure. Fixed-interval performance was disrupted by exposures to CS/sub 2/ and doses of FLA-63 that left fixed-ratio performance intact.
- Research Organization:
- Univ. of Rochester, NY
- OSTI ID:
- 7317422
- Journal Information:
- J. Pharmacol. Exp. Ther.; (United States), Journal Name: J. Pharmacol. Exp. Ther.; (United States) Vol. 199:3; ISSN JPETA
- Country of Publication:
- United States
- Language:
- English
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