Hypothyroidism after x irradiation to the neck: three case reports and a brief review of the literature
Three patients who developed hypothyroidism after x irradiation to the neck are presented. The first two cases demonstrate that patients can develop clinical and chemical hypothyroidism after a very short interval following radiotherapy. Hypothyroidism developed in the first patient in the absence of surgical manipulation of the neck, or a large iodine load 4 months after receiving 6800 rad of x-ray therapy to his neck for carcinoma of the larynx. The second patient developed hypothyroidism approximately 6 months after his radiotherapy for carcinoma of the esophagus. Both of these patients demonstrated high titers of serum antithyroid antibodies. A third patient with Hodgkin's disease did not manifest clinical symptoms and signs of hypothyroidism until 6 years after radiation therapy. These cases demonstrate the variability of onset of hypothyroidism after radiotherapy and emphasize the need for careful evaluation of thyroid function before and after neck irradiation.
- Research Organization:
- Walter Reed Army Medical Center, Washington, DC
- OSTI ID:
- 7317063
- Journal Information:
- Johns Hopkins Med. J.; (United States), Vol. 138:5
- Country of Publication:
- United States
- Language:
- English
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HYPOTHYROIDISM
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LARYNX
PATIENTS
X RADIATION
BIOLOGICAL EFFECTS
BODY
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
ENDOCRINE DISEASES
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IONIZING RADIATIONS
MEDICINE
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NUCLEAR MEDICINE
ORGANS
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560151* - Radiation Effects on Animals- Man