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Title: Thyroid cancer following radiotherapy for Hodgkin's disease: a case report and review of the literature

Abstract

Improved survival resulting from advances in therapy in patients with Hodgkin's disease is associated with long-term morbidity, including the potential for the development of a second solid malignancy. We report a 44-year-old man with an unusually aggressive course of thyroid carcinoma 15 years after treatment for Hodgkin's disease. In a review of the English-language literature, we found 21 cases of thyroid cancer following radiotherapy for Hodgkin's disease, with latency periods ranging from 6 to 48 years. The development of secondary thyroid cancer after high-dose neck irradiation may be related to hypothyroidism, itself a complication of radiotherapy. Thyroid function should be measured at least once a year in all patients given neck irradiation, with initiation of thyroid hormone replacement if there is evidence of sustained hypothyroidism.

Authors:
;
Publication Date:
Research Org.:
Albert Einstein College of Medicine, Bronx, NY
OSTI Identifier:
5004812
Resource Type:
Journal Article
Journal Name:
Med. Pediatr. Oncol.; (United States)
Additional Journal Information:
Journal Volume: 4
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; HODGKINS DISEASE; RADIOTHERAPY; SIDE EFFECTS; THYROID; CARCINOMAS; DELAYED RADIATION EFFECTS; HYPOTHYROIDISM; RADIOINDUCTION; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; DISEASES; ENDOCRINE DISEASES; ENDOCRINE GLANDS; GLANDS; LYMPHOMAS; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; ORGANS; RADIATION EFFECTS; RADIOLOGY; THERAPY; 560151* - Radiation Effects on Animals- Man

Citation Formats

Moroff, S V, and Fuks, J Z. Thyroid cancer following radiotherapy for Hodgkin's disease: a case report and review of the literature. United States: N. p., 1986. Web. doi:10.1002/mpo.2950140406.
Moroff, S V, & Fuks, J Z. Thyroid cancer following radiotherapy for Hodgkin's disease: a case report and review of the literature. United States. doi:10.1002/mpo.2950140406.
Moroff, S V, and Fuks, J Z. Wed . "Thyroid cancer following radiotherapy for Hodgkin's disease: a case report and review of the literature". United States. doi:10.1002/mpo.2950140406.
@article{osti_5004812,
title = {Thyroid cancer following radiotherapy for Hodgkin's disease: a case report and review of the literature},
author = {Moroff, S V and Fuks, J Z},
abstractNote = {Improved survival resulting from advances in therapy in patients with Hodgkin's disease is associated with long-term morbidity, including the potential for the development of a second solid malignancy. We report a 44-year-old man with an unusually aggressive course of thyroid carcinoma 15 years after treatment for Hodgkin's disease. In a review of the English-language literature, we found 21 cases of thyroid cancer following radiotherapy for Hodgkin's disease, with latency periods ranging from 6 to 48 years. The development of secondary thyroid cancer after high-dose neck irradiation may be related to hypothyroidism, itself a complication of radiotherapy. Thyroid function should be measured at least once a year in all patients given neck irradiation, with initiation of thyroid hormone replacement if there is evidence of sustained hypothyroidism.},
doi = {10.1002/mpo.2950140406},
journal = {Med. Pediatr. Oncol.; (United States)},
number = ,
volume = 4,
place = {United States},
year = {1986},
month = {1}
}