Thyroid cancer following radiotherapy for Hodgkin's disease: a case report and review of the literature
Improved survival resulting from advances in therapy in patients with Hodgkin's disease is associated with long-term morbidity, including the potential for the development of a second solid malignancy. We report a 44-year-old man with an unusually aggressive course of thyroid carcinoma 15 years after treatment for Hodgkin's disease. In a review of the English-language literature, we found 21 cases of thyroid cancer following radiotherapy for Hodgkin's disease, with latency periods ranging from 6 to 48 years. The development of secondary thyroid cancer after high-dose neck irradiation may be related to hypothyroidism, itself a complication of radiotherapy. Thyroid function should be measured at least once a year in all patients given neck irradiation, with initiation of thyroid hormone replacement if there is evidence of sustained hypothyroidism.
- Research Organization:
- Albert Einstein College of Medicine, Bronx, NY
- OSTI ID:
- 5004812
- Journal Information:
- Med. Pediatr. Oncol.; (United States), Vol. 4
- Country of Publication:
- United States
- Language:
- English
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HODGKINS DISEASE
RADIOTHERAPY
SIDE EFFECTS
THYROID
CARCINOMAS
DELAYED RADIATION EFFECTS
HYPOTHYROIDISM
RADIOINDUCTION
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
LYMPHOMAS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
THERAPY
560151* - Radiation Effects on Animals- Man