Influence of dietary selenite on the binding characteristics of rat serum proteins to mercurial compounds
Journal Article
·
· Chem.-Biol. Interact.; (United States)
The effect of dietary selenite on the binding characteristics of serum proteins was investigated with rats. In the control serum, the maximal binding of phenylmercuric acetate (PMA) and methylmercuric chloride (MMC) to rat serum protein was approx. 18 and 9 nmoles per mg protein, respectively. The binding of Hg/sup 2 +/ was biphasic and it did not reach a maximum at the concentrations used. Selenite treatment caused a reduction in binding capacity of serum proteins to Hg/sup 2 +/ and PMA, and an increase in the binding affinities. However, there were no such changes for the binding of MMC. Selenite protection from mercury toxicity, therefore, acts not only via a change in tissue distribution and a change in the formation of seleno-proteins but, also, via a change in the binding characteristics to some mercury compounds. In the case of methylmercury, a different mechanism of protection must exist as the modification of tissue distribution, its binding to subcellular and soluble proteins and the binding characteristics remained equivocal.
- Research Organization:
- Oregon State Univ., Corvallis
- OSTI ID:
- 7312197
- Journal Information:
- Chem.-Biol. Interact.; (United States), Journal Name: Chem.-Biol. Interact.; (United States) Vol. 15:1; ISSN CBINA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Binding of various mercurial compounds to serum proteins
Bis(methylmercuric) selenide as a reaction product from methylmercury and selenite in rabbit blood
Interaction of alkylmercuric compounds with sodium selenite. III. Biotransformation, levels of metallothioneinlike proteins and endogenous copper in some tissues of rats exposed to methyl or ethylmercuric chloride with and without sodium selenite
Journal Article
·
Wed Dec 31 23:00:00 EST 1975
· Bull. Environ. Contam. Toxicol.; (United States)
·
OSTI ID:7240315
Bis(methylmercuric) selenide as a reaction product from methylmercury and selenite in rabbit blood
Journal Article
·
Mon Dec 31 23:00:00 EST 1979
· Res. Commun. Chem. Pathol. Pharmacol.; (United States)
·
OSTI ID:6119226
Interaction of alkylmercuric compounds with sodium selenite. III. Biotransformation, levels of metallothioneinlike proteins and endogenous copper in some tissues of rats exposed to methyl or ethylmercuric chloride with and without sodium selenite
Journal Article
·
Wed May 01 00:00:00 EDT 1985
· Environ. Health Perspect.; (United States)
·
OSTI ID:6080263
Related Subjects
550500* -- Metabolism
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
BLOOD SERUM
DIET
DISTRIBUTION
ELEMENTS
KINETICS
MAMMALS
MERCURY
METALS
NUTRITION
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
PROTEINS
RATS
REACTION KINETICS
RODENTS
SELENITES
SELENIUM COMPOUNDS
TISSUE DISTRIBUTION
TOXICITY
VERTEBRATES
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
BLOOD SERUM
DIET
DISTRIBUTION
ELEMENTS
KINETICS
MAMMALS
MERCURY
METALS
NUTRITION
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
PROTEINS
RATS
REACTION KINETICS
RODENTS
SELENITES
SELENIUM COMPOUNDS
TISSUE DISTRIBUTION
TOXICITY
VERTEBRATES