Binding of various mercurial compounds to serum proteins
Journal Article
·
· Bull. Environ. Contam. Toxicol.; (United States)
Binding study of /sup 203/Hg-labeled Hg/sup 2 +/, phenylmercuric acetate (PMA), methylmercuric chloride (MMC) and ethylmercuric chloride (EMC) to serum albumin of six mammalian species, bovine hemoglobin and bovine ..gamma..-globulin is presented. Both MMC and EMC bound only weakly to serum albumin and ..gamma..-globulin and more strongly to hemoglobin; Hg/sup 2 +/ bound very strongly to both albumin and hemoglobin and weakly to ..gamma..-globulin; and PMA bound most strongly to albumin, next to hemoglobin, and the least to ..gamma..-globulin. The available binding sites varied from one to five per molecule of protein. Human serum albumin has the lowest association constants with all four mercurial compounds, indicating that it was not as tightly bound to mercurial compounds as found with serum albumins from other species.
- Research Organization:
- Oregon State Univ., Corvallis
- OSTI ID:
- 7240315
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 15:1; ISSN BECTA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
510200 -- Environment
Terrestrial-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
ALBUMINS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMISTRY
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
CARBOXYLIC ACIDS
CATTLE
CHEMISTRY
DAYS LIVING RADIOISOTOPES
DOMESTIC ANIMALS
EVEN-ODD NUCLEI
GLOBIN
GLOBULINS
GLOBULINS-GAMMA
HEAVY NUCLEI
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HORSES
ISOTOPES
MAMMALS
MAN
MERCURY 203
MERCURY COMPOUNDS
MERCURY ISOTOPES
METABOLISM
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PRIMATES
PROTEINS
RABBITS
RADIOISOTOPES
RUMINANTS
SHEEP
SWINE
VERTEBRATES
Terrestrial-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
ALBUMINS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMISTRY
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
CARBOXYLIC ACIDS
CATTLE
CHEMISTRY
DAYS LIVING RADIOISOTOPES
DOMESTIC ANIMALS
EVEN-ODD NUCLEI
GLOBIN
GLOBULINS
GLOBULINS-GAMMA
HEAVY NUCLEI
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HORSES
ISOTOPES
MAMMALS
MAN
MERCURY 203
MERCURY COMPOUNDS
MERCURY ISOTOPES
METABOLISM
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PRIMATES
PROTEINS
RABBITS
RADIOISOTOPES
RUMINANTS
SHEEP
SWINE
VERTEBRATES