LET-dependent radiosensitivity of Escherichia coli K-12 rec and uvr mutants. [Alpha particles]

Journal Article · Fri Jul 01 04:00:00 EDT 1977 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574727· OSTI ID:7312095

Yatagai, F; Matsuyama, A

Escherichia coli K-12 AB1157 (rec/sup +/uvr/sup +/), AB2500 (uvrA), AB2470 (recB), and JC1553 (recA), which have different DNA repair capacity, were bombarded with ..cap alpha.. particles, C ions, and N ions having various beam energies in order to determine the LET-dependent radiosensitivity. Radiosensitivity of the uvrA mutant was almost the same as that of the wild-type throughout the whole LET region studied. Difference in radiosensitivity between the rec- mutants and the wild-type was found to decrease with increasing LET of charged particles used. Such LET dependence can be explained by the increase in the ratio of irreparable to reparable-type damages in DNA with the increasing LET of the particles. It is also possible that a significant component of the LET-dependent changes in viability observed may be due to damages to the repair system itself.

• Research Organization: Inst. of Physical and Chemical Research, Saitama, Japan
• OSTI ID: 7312095
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 71:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALPHA PARTICLES
ATOMIC IONS
BACTERIA
CARBON IONS
CHARGED PARTICLES
DNA
ENERGY TRANSFER
ESCHERICHIA COLI
IONS
LET
MICROORGANISMS
MUTANTS
NITROGEN IONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS