Methoxyflurane: I. An overview. II. An abstracted literature collection, 1947--1976

Technical Report · Fri Jul 01 00:00:00 EDT 1977

OSTI ID:7308355

Waters, E M; Ricci, B E

Evidence presented in the literature suggests that methoxyflurane (Penthrane) (MOF) is a potent and efficacious anesthetic. At the same time, however, observed adverse reactions indicate that additional data are needed to determine the feasibility for continued widespread use of MOF. Experimental and clinical evidence clearly demonstrates that the ionic metabolites of MOF (fluoride and oxalate ions) are the toxic moieties responsible for the resultant physiologic maladies. This report on methoxyflurane is comprised of an overview and an abstracted literature collection.

• Research Organization: Toxicology Information Response Center, Oak Ridge, TN (USA)
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 7308355
• Report Number(s): ORNL/TIRC-77/2
• Country of Publication: United States
• Language: English

Related Subjects

550600 -- Medicine
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANESTHETICS
BIBLIOGRAPHIES
BIOLOGICAL EFFECTS
CARBOXYLIC ACID SALTS
DOCUMENT TYPES
DRUGS
FLUORIDES
FLUORINE COMPOUNDS
HALIDES
HALOGEN COMPOUNDS
MEDICAL PERSONNEL
METABOLISM
OXALATES
PATIENTS
PERSONNEL
TOXICITY