Quantification of infarct size. Annual report, 30 Jun 1975--15 Apr 1976

Technical Report · Wed Apr 14 04:00:00 EST 1976

OSTI ID:7306870

Block, P C; Khaw, B

The project is designed to show that purified anti-cardiac myosin (or fragments thereof) will (1) localize in areas of myocardial damage; and (2) provide a useful tool for measuring the extent of such damage. Anti-myosin localization was enhanced by using (Fab1)2 fragments of anti-myosin - especially when (Fab1)2 uptake was determined at 72 hours after coronary occlusion in experimental animals. There is an inverse exponential relationship between anti-myosin (Fab1)2 localization and regional myocardial blood flow as determined by microsphere studies. Preliminary myocardial infarct Anger camera imaging was performed using Iodine-131 labelled anti-myosin (Fab1)2 fragments. 'Hot spot' images of myocardial infarction were superimposed on 'cold spot' images produced by radioactive microspheres in the same area of infarction. Thus, radioactive anti-myosin antibody fragments can be used to localize myocardial infarction in vivo by myocardial Anger camera imaging. Further refinements in techniques will hopefully allow imaging and 'sizing' of myocardial infarction in man.

• Research Organization: Massachusetts General Hospital, Boston (USA)
• OSTI ID: 7306870
• Report Number(s): PB-262043
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
HEART
IMMUNOLOGY
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING