Derivation of survival kinetic parameters for cell populations by computer simulation of radiobiological data. [X radiation, neutrons, mice]
The single-hit multitarget cellular lethality model requires four to six parameters in order to simulate a complete course of fractionated radiation therapy and derives an estimate of the cellular-surviving fraction for a given treatment scheme. These parameters are the mean cellular lethal dose, the extrapolation number, the ratio of sublethal to irreparable events, the regeneration rate, and, in some instances, the repopulation limit (cell cycles), and a field-size or tumor-volume factor. If a number of different fractionation schemes yield similar reactions, the surviving fractions are presumed to be about equal in each instance. Under these circumstances, an equivalent number of simultaneous equations can be set up and the unknown parameters then derived by iterative numerical methods. A computer program was designed for this purpose and tested on available clinical and experimental data. Parameters were derived for skin tolerance and cure of epidermoid cancer in man, for radiation reactions in pig skin, rat spinal cord, various mouse tissues, and for control of mouse mammary carcinoma irradiated in situ. In some systems analogous parameters could be obtained for both X rays and neutrons, thus providing the coefficients required to calculate neutron RBE's for these tissues.
- Research Organization:
- Michael Reese Medical Center, Chicago
- OSTI ID:
- 7306778
- Journal Information:
- Radiat. Res.; (United States), Vol. 69:3; Conference: 23. annual meeting of the Radiation Research Society, Miami Beach, FL, USA, 11 May 1975
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ANIMAL CELLS
BIOLOGICAL RADIATION EFFECTS
COMPUTERS
FRACTIONATED IRRADIATION
MATHEMATICAL MODELS
MICE
NEUTRONS
POPULATIONS
SURVIVAL CURVES
X RADIATION
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
FERMIONS
HADRONS
IONIZING RADIATIONS
IRRADIATION
MAMMALS
NUCLEONS
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)